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About REVLIMID® (lenalidomide) treatment for deletion 5q myelodysplastic syndromes, mantle cell lymphoma and multiple myeloma including full indications, dosing, administration, efficacy, safety & prescribing information. Important Safety Information WARNING: Risk to unborn babies, low blood counts, and blood clots Before you begin taking REVLIMID, you must read and agree to all of the instructions in the REVLIMID REMS® program (formerly known as the RevAssist® program). REVLIMID may cause serious side effects including: Possible birth defects (deformed babies) or *** of an unborn baby. Females who are pregnant or who plan to become pregnant must not take REVLIMID. REVLIMID is similar to the medicine thalidomide (THALOMID®). We know thalidomide can cause severe life-threatening birth defects. REVLIMID has not been tested in pregnant females. REVLIMID has harmed unborn animals in animal testing. In females of childbearing potential, obtain 2 negative pregnancy tests before starting REVLIMID treatment. Females must not get pregnant: for at least 4 weeks before starting REVLIMID while taking REVLIMID during any breaks (interruptions) in your treatment with REVLIMID for at least 4 weeks after stopping REVLIMID If you become pregnant while taking REVLIMID, stop taking it right away and call your healthcare provider. REVLIMID causes low white blood cells (neutropenia) and low platelets (thrombocytopenia) in most patients. REVLIMID causes a higher chance for blood clots in your veins (deep vein thrombosis), lungs (pulmonary ***), and arteries (heart attack or stroke). Risk to Unborn Babies REVLIMID may cause serious birth defects or *** of an unborn baby. Do not get pregnant while taking REVLIMID. Females who can become pregnant Will have pregnancy tests weekly for 4 weeks, then every 4 weeks if your menstrual cycle is regular, or every 2 weeks if your menstrual cycle is irregular If you miss your period or have unusual bleeding, you will need to have a pregnancy test and receive counseling Must agree to use 2 different forms of effective birth control at the same time every time for 4 weeks before, while taking, during any breaks (interruptions) in your treatment, and for 4 weeks after stopping REVLIMID If you become pregnant while taking REVLIMID, stop taking it right away and call your healthcare provider. If your healthcare provider is not available, you can call 1-888-668-2528 for medical information. Healthcare providers and patients should report all cases of pregnancy to: FDA MedWatch at 1-800-FDA-1088 and Celgene Corporation at 1-888-423-5436 Do not get pregnant and do not breastfeed while taking REVLIMID. REVLIMID must not be used by females who are pregnant or breastfeeding. It is not known if REVLIMID passes into your breast milk and harms your baby Males REVLIMID can pass into human ***. Males, including those who have had a vasectomy, must use a *** or synthetic *** during any *** contact with a pregnant female or a female who can become pregnant. Males must do this while taking REVLIMID, during any breaks (interruptions) in your treatment with REVLIMID, and for 4 weeks after stopping REVLIMID. (If you or your partner are allergic to ***, please consult with your healthcare provider) Do not have unprotected *** contact with a female who is or could become pregnant. Tell your healthcare provider if you do have unprotected *** contact with a female who is or could become pregnant. Men, if your female partner becomes pregnant, you should call your healthcare provider right away Do not donate sperm while taking REVLIMID, during any breaks (interruptions) in your treatment with REVLIMID, and for 4 weeks after stopping REVLIMID. If a female becomes pregnant with your sperm, the baby may be exposed to REVLIMID and may be born with birth defects Females and Males Do not share REVLIMID with other people. It may cause birth defects and other serious problems Do not donate blood while you take REVLIMID, during any breaks (interruptions) in your treatment, and for 4 weeks after stopping REVLIMID. If someone who is pregnant gets your donated blood, her baby may be exposed to REVLIMID and may be born with birth defects Low white blood cells (neutropenia) and low platelets (thrombocytopenia) REVLIMID causes low white blood cells and low platelets in most people. You may need a blood transfusion or certain medicines if your blood counts drop too low Your healthcare provider should check your blood counts often especially during the first several months of treatment with REVLIMID, and then at least monthly. Tell your healthcare provider if you develop any bleeding or bruising during treatment with REVLIMID Blood clots Blood clots in the arteries, veins, and lungs happen more often in people who take REVLIMID Risk is even higher for people with multiple myeloma taking REVLIMID with dexamethasone Heart attacks and stroke also happen more often in people taking REVLIMID with dexamethasone To reduce this increased risk, most people who take REVLIMID will also take a blood thinner medicine Before taking REVLIMID tell your healthcare provider: if you have had a blood clot in the past, have high blood pressure, you smoke, you have been told you have high level of fat in your blood (hyperlipidemia), and all medicines you take. Certain other medicines can also increase your risk for blood clots Call your healthcare provider or get medical help right away if you get any of the following signs or symptoms during treatment with REVLIMID: Blood clot in lung, arm or leg: shortness of breath, chest pain, or arm or leg swelling. Heart attack: chest pain that may spread to arms, neck, jaw, back or stomach area, feeling sweaty, shortness of breath, feeling sick or vomiting. Stroke: sudden numbness or weakness, especially on one side of the body, severe headache or confusion, or problems with vision, speech or balance Other serious side effects Increased risk of *** in people who have chronic lymphocytic leukemia (CLL). People with CLL who take REVLIMID have an increased risk of *** compared with people who take the medicine chlorambucil. REVLIMID may cause you to have serious heart problems that can lead to ***, including atrial fibrillation, heart attack, or heart failure. You should not take REVLIMID if you have CLL unless you are participating in a controlled clinical trial Risk of new cancers (malignancies). People with MM who receive REVLIMID and melphalan and a blood stem cell transplant have a higher risk of developing new cancers, including certain blood cancers (acute myelogenous leukemia or AML and myelodysplastic syndrome or MDS) and a type of lymphoma called Hodgkin lymphoma. Talk with your healthcare provider about your risk of developing new cancers if you take REVLIMID. Your healthcare provider will check you for new cancers during your treatment with REVLIMID Severe liver problems, including liver failure and ***. Tell your healthcare provider right away if you develop any of the following symptoms: yellowing of your skin or the white part of your eyes (jaundice), dark or brown (tea colored) urine, pain on the upper right side of your stomach area, bleeding or bruising more easily than normal, and feeling very tired. Your healthcare provider will do blood tests to check your liver function during treatment with REVLIMID Serious allergic reactions and serious skin reactions can happen with REVLIMID and may cause ***. Call your healthcare provider right away if you develop any of these signs or symptoms of serious allergic reaction or serious skin reaction: swelling of your face, eyes, lips, tongue, throat; trouble swallowing or breathing, skin rash, hives or peeling of your skin and blisters Allergic reactions. Tell your healthcare provider if you are lactose intolerant as REVLIMID contains lactose Tumor lysis syndrome. Metabolic complications that can occur during treatment of *** and sometimes even without treatment. These complications are caused by the breakdown products of *** *** cells and may include the following: changes to blood chemistry, high potassium, phosphorus, uric acid, and lo
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